Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …

Exercise is the most important physiological stimulus for increased myocardial oxygen
demand. The requirement of exercising muscle for increased blood flow necessitates an …

The beating heart creates blood pressure and flow pulsations that propagate as waves
through the arterial tree that are reflected at transitions in arterial geometry and elasticity …

Blood flow (BF) increases with increasing exercise intensity in skeletal, respiratory, and
cardiac muscle. In humans during maximal exercise intensities, 85% to 90% of total cardiac …

Background—Coronary blood flow peaks in diastole when aortic blood pressure has fallen.
Current models fail to completely explain this phenomenon. We present a new approach …

The blood vessels that run on the surface of the heart and through its muscle are compliant
tubes that can be affected by the pressures external to them in at least two ways. If the …

Hearts of 11 anesthetized open-chest dogs were paced from the right atrium (RA), right
ventricular outflow tract (RVOT), and left ventricular apex (LVA). Maps of the sequence of …

Abbreviations: AHI= apnea! hypopnea index; CPAP= continuous positive airway pressure;
NREM= nonrapid eye movement; Pcrit= critical pressure; Pds= pressure downstream to the …