Mycobacterium tuberculosis (MTB) has co-evolved with humans for decades and developed
several mechanisms to evade host immunity. It can efficiently alter the host epigenome, thus …

We hypothesized that DNA methylation patterns may contribute to the development of active
pulmonary tuberculosis (TB). Illumina's DNA methylation 450 K assay was used to identify …

Introduction Ras guanine nucleotide-releasing protein-4 (RasGRP4) is an activator of Ras
protein, which plays significant roles in both the inflammatory response and immune …

Importance Diagnostic genetic testing can lead to changes in management in the pediatric
intensive care unit. Genetic risk in children with critical illness but nondiagnostic exome …

2 diabetes. Herein, we delved into the specific role and mechanism of RasGRP4 in 23
diabetic renal ischemia-reperfusion injury. Diabetes was induced by a high-fat diet 24 and …

Diffuse large B cell lymphoma (DLBCL) is successfully treated with combination immuno-
chemotherapy, but relapse with resistant disease occurs in~ 40% of patients. However, little …

Rapid genetic sequencing is an established and important clinical tool for management of
pediatric critical illness. The burden of risk variants in children with critical illness but a non …

Although universal and unavoidable, aging does not occur in a uniform way. In this
dissertation, we assessed the effects of early life exposure to pro-inflammatory risk factors …