Challenges and opportunities for the next generation of cardiovascular tissue engineering
Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …
Genomic frontiers in congenital heart disease
The application of next-generation sequencing to study congenital heart disease (CHD) is
increasingly providing new insights into the causes and mechanisms of this prevalent birth …
increasingly providing new insights into the causes and mechanisms of this prevalent birth …
SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19
Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of
patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell …
patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell …
Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease
C Hall, K Gehmlich, C Denning… - Journal of the American …, 2021 - Am Heart Assoc
Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix
in the heart, providing support to the contracting myocardium and contributing to a myriad of …
in the heart, providing support to the contracting myocardium and contributing to a myriad of …
Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …
modeling and have unlocked new possibilities for understanding the mechanisms governing …
Opportunities and challenges in cardiac tissue engineering from an analysis of two decades of advances
Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …
modelling and drug development. In this Perspective, we reflect on the most notable …
Cellular and engineered organoids for cardiovascular models
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review
This paper aims to provide an important update on the recent preclinical and clinical trials
using cell therapy strategies and engineered heart tissues for the treatment of postinfarction …
using cell therapy strategies and engineered heart tissues for the treatment of postinfarction …
Chromatin remodelling drives immune cell–fibroblast communication in heart failure
Chronic inflammation and tissue fibrosis are common responses that worsen organ function,
yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased …
yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased …
Utility of iPSC-derived cells for disease modeling, drug development, and cell therapy
MW Nicholson, CY Ting, DZH Chan, YC Cheng… - Cells, 2022 - mdpi.com
The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …