Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

Neurodegenerative diseases are disabling and fatal neurological disorders that currently
lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a …

Neural stem cell (NSC) transplantation induces recovery in animal models of central
nervous system (CNS) diseases. Although the replacement of lost endogenous cells was …

Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

Although the initial concepts of stem cell therapy aimed at replacing lost tissue, more recent
evidence has suggested that stem and progenitor cells alike promote postischemic …

Aging accounts for increased risk and dismal outcome of ischemic stroke. Here, we
investigated the impact of age-related changes in the immune system on stroke. Upon …

Transplantation of dopaminergic neurons can potentially improve the clinical outcome of
Parkinson's disease, a neurological disorder resulting from degeneration of mesencephalic …

Ischemic stroke is a leading cause of death worldwide. A key secondary cell death
mechanism mediating neurological damage following the initial episode of ischemic stroke …

Extracellular vesicles (EVs) are a heterogeneous population of secreted membrane
vesicles, with distinct biogenesis routes, biophysical properties and different functions both …

Over the past several decades, there have been substantial advances in our knowledge of
the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to …