[HTML][HTML] Stabilization effects of saccharides in protein formulations: A review of sucrose, trehalose, cyclodextrins and dextrans
Saccharides are a popular group of stabilizers in liquid, frozen and freeze dried protein
formulations. The current work reviewed the stabilization mechanisms of three groups of …
formulations. The current work reviewed the stabilization mechanisms of three groups of …
Small-angle neutron scattering contrast variation studies of biological complexes: Challenges and triumphs
S Krueger - Current opinion in structural biology, 2022 - Elsevier
Small-angle neutron scattering (SANS) has been a beneficial tool for studying the structure
of biological macromolecules in solution for several decades. Continued improvements in …
of biological macromolecules in solution for several decades. Continued improvements in …
Role of Poloxamer 188 in preventing ice-surface-induced protein destabilization during freeze–thawing
J Li, J Sonje, R Suryanarayanan - Molecular pharmaceutics, 2023 - ACS Publications
The phase behavior of poloxamer 188 (P188) in aqueous solutions, characterized by
differential scanning calorimetry (DSC) and synchrotron X-ray diffractometry, revealed solute …
differential scanning calorimetry (DSC) and synchrotron X-ray diffractometry, revealed solute …
Poly(l-alanine-co-l-threonine succinate) as a Biomimetic Cryoprotectant
We synthesized a series of [(l-Ala) x-co-(l-Thr succinate) y](PATs), which are analogous to
natural antifreezing glycoprotein with the structure of [l-Ala-l-Ala-l-Thr disaccharide] n, by …
natural antifreezing glycoprotein with the structure of [l-Ala-l-Ala-l-Thr disaccharide] n, by …
Enabling efficient design of biological formulations through advanced characterization
The present review summarizes the use of differential scanning calorimetry (DSC) and
scattering techniques in the context of protein formulation design and characterization. The …
scattering techniques in the context of protein formulation design and characterization. The …
Cationic polyelectrolytes prevent the aggregation of l-lactate dehydrogenase under unstable conditions
Unstructured biological macromolecules have attracted attention as protein aggregation
inhibitors in living cells. Some are characterized by their free structural configuration, highly …
inhibitors in living cells. Some are characterized by their free structural configuration, highly …
Molecular Dynamics Modeling Based Investigation of the Effect of Freezing Rate on Lysozyme Stability
Purpose The stability of protein drug products frozen during fill finish operations is greatly
affected by the freezing rate applied. Non-optimal freezing rates may lead to the …
affected by the freezing rate applied. Non-optimal freezing rates may lead to the …
Study of Oncolytic Virus Preservation and Formulation
L Pan, X Liu, D Fan, Z Qian, X Sun, P Wu, L Zhong - Pharmaceuticals, 2023 - mdpi.com
In recent years, oncolytic viruses (OVs) have emerged as an effective means of treating
cancer. OVs have multiple oncotherapeutic functions including specifically infecting and …
cancer. OVs have multiple oncotherapeutic functions including specifically infecting and …
Two populations of protein molecules detected by small-angle neutron and X-ray scattering (SANS and SAXS) in lyophilized protein: lyoprotector (disaccharide) …
Two protein interaction peaks are observed in pharmaceutically-relevant protein (serum
albumin): disaccharide 1: 1 and 1: 3 (w/w) freeze-dried systems for the first time. In samples …
albumin): disaccharide 1: 1 and 1: 3 (w/w) freeze-dried systems for the first time. In samples …
Professor Raj Suryanarayanan: Scientist, Educator, Mentor, Family Man and Giant in Pharmaceutical Research
P Chakravarty, A Dash, E Shalaev, CC Sun… - Journal of …, 2023 - Elsevier
This special edition of the Journal of Pharmaceutical Sciences is dedicated to Professor Raj
Suryanarayanan (Professor and William & Mildred Peters Endowed Chair, University of …
Suryanarayanan (Professor and William & Mildred Peters Endowed Chair, University of …