G protein–coupled receptors (GPCRs) represent the largest family of plasma membrane
proteins targeted for therapeutic development. For decades, GPCRs were investigated as …

The traditional view on GPCRs held that they function as single monomeric units composed
of identical subunits. This notion was overturned by the discovery that GPCRs can form …

Polydopamine (PDA)-coated nanoparticles (NPs) are emerging carriers of therapeutic
agents for nanomedicine applications due to their biocompatibility and abundant entry to …

Depression and anxiety are more common among females than males and represent a
leading cause of disease-related disability in women. Since the dopamine D1-D2 heteromer …

Dopamine and its receptors are currently recognized targets for the treatment of several
neuropsychiatric disorders, including Parkinson's disease, schizophrenia, some drug use …

Introduction: Several types of D2R and D1R heteroreceptor complexes were discovered in
the indirect and direct pathways of the striatum, respectively. The hypothesis is given that …

A significant subpopulation of neurons in rat nucleus accumbens (NAc) coexpress
dopamine D1 and D2 receptors, which can form a D1-D2 receptor complex, but their …

The introduction of super‐resolution fluorescence microscopy has allowed the visualization
of single proteins in their biological environment. Recently, these techniques have been …

Heteromerization of G protein–coupled receptors (GPCRs) can significantly change the
functional properties of involved receptors. Various biochemical and biophysical …

Dopaminergic neurons in the ventral tegmental area, the major midbrain nucleus projecting
to the motor cortex, play a key role in motor skill learning and motor cortex synaptic plasticity …