Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a
binary classification of chemical entities. For more than a decade, there has been a …

Hydroxyurea (hydroxycarbamide) is approved for treating both children and adults with
sickle cell anaemia (SCA). Fetal haemoglobin (HbF) induction is the primary treatment …

The in vivo Pig-a assay uses flow cytometry to measure phenotypic variants for antibody
binding to cell surface glycosylphosphatidylinositol (GPI)-anchored proteins. There is good …

The working group reached complete or majority agreement on many issues. Results from
TGR and in vivo comet assays for 91 chemicals showed they have similar ability to detect in …

A collaborative international trial was conducted to evaluate the reproducibility and
transferability of an in vivo mutation assay based on the enumeration of CD59‐negative rat …

This laboratory has previously described a method for scoring the incidence of rodent blood
Pig‐a mutant phenotype erythrocytes using immunomagnetic separation in conjunction with …

Abstract The X-linked PIG-A gene is involved in the biosynthesis of the cell surface anchor
GPI, and its inactivation may serve as a new marker for mutagenicity. The in vivo PIG-A gene …

The peripheral blood Pig-a assay has shown promise as a tool for evaluating in vivo
mutagenicity. In this study five laboratories participated in a collaborative trial that evaluated …

The rodent Pig‐a assay is a flow cytometric, phenotype‐based method used to measure in
vivo somatic cell mutation. An Organization for Economic Co‐operation and Development …

An international collaborative trial was established to systematically investigate the merits
and limitations of a rat in vivo Pig‐a gene mutation assay. The product of this gene is …