Surgical repair of severe peripheral nerve injuries represents not only a pressing medical
need, but also a great clinical challenge. Autologous nerve grafting remains a golden …

▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …

Functional recovery from peripheral nerve injury and repair depends on a multitude of
factors, both intrinsic and extrinsic to neurons. Neuronal survival after axotomy is a …

In spite of an enormous amount of new experimental laboratory data based on evolving
neuroscientific concepts during the last 25 years peripheral nerve injuries still belong to the …

DURING vertebrate development, neuronal survival depends on target-derived neurotrophic
factors1, 2. Brain-derived neurotrophic factor3 (BDNF), a member of the neurotrophin family …

For survival, embryonic motoneurons in vertebrates depend on as yet undefined
neurotrophic factors present in the limb bud. Members of the neurotrophin family are …

The peripheral nervous system retains a considerable capacity for regeneration. However,
functional recovery rarely returns to the preinjury level no matter how accurate the nerve …

Nerve growth factor (NGF) has long occupied a central position in developmental
neurobiology because of the many important neuronal functions it has been shown to …

The signaling mechanisms that control the survival of CNS neurons are poorly understood.
Here we show that, in contrast to PNS neurons, the survival of purified postnatal rat retinal …

Over a half a century of research has confirmed that neurotrophic factors promote the
survival and process outgrowth of isolated neurons in vitro. The mechanisms by which …