A guide to the organ-on-a-chip

CM Leung, P De Haan… - Nature Reviews …, 2022 - nature.com
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Experimental perspective on three-dimensional topological semimetals

BQ Lv, T Qian, H Ding - Reviews of Modern Physics, 2021 - APS
Topological semimetals (TSMs) are characterized by bulk band crossings in their electronic
structures, which are expected to give rise to gapless electronic excitations and topological …

Materials-driven soft wearable bioelectronics for connected healthcare

S Gong, Y Lu, J Yin, A Levin, W Cheng - Chemical Reviews, 2024 - ACS Publications
In the era of Internet-of-things, many things can stay connected; however, biological
systems, including those necessary for human health, remain unable to stay connected to …

Functional neuronal circuitry and oscillatory dynamics in human brain organoids

T Sharf, T Van Der Molen, SMK Glasauer… - Nature …, 2022 - nature.com
Human brain organoids replicate much of the cellular diversity and developmental anatomy
of the human brain. However, the physiology of neuronal circuits within organoids remains …

Organic Bioelectronics for In Vitro Systems

C Pitsalidis, AM Pappa, AJ Boys, Y Fu… - Chemical …, 2021 - ACS Publications
Bioelectronics have made strides in improving clinical diagnostics and precision medicine.
The potential of bioelectronics for bidirectional interfacing with biology through continuous …

Experimental validation of the free-energy principle with in vitro neural networks

T Isomura, K Kotani, Y Jimbo, KJ Friston - Nature Communications, 2023 - nature.com
Empirical applications of the free-energy principle are not straightforward because they
entail a commitment to a particular process theory, especially at the cellular and synaptic …

Electrophysiological analysis of brain organoids: current approaches and advancements

AP Passaro, SL Stice - Frontiers in Neuroscience, 2021 - frontiersin.org
Brain organoids, or cerebral organoids, have become widely used to study the human brain
in vitro. As pluripotent stem cell-derived structures capable of self-organization and …

Emerging bioelectronics for brain organoid electrophysiology

K Tasnim, J Liu - Journal of molecular biology, 2022 - Elsevier
Human brain organoids are generated from three-dimensional (3D) cultures of human
induced pluripotent stem cells and embryonic stem cells, which partially replicate the …

Spike sorting: new trends and challenges of the era of high-density probes

AP Buccino, S Garcia, P Yger - Progress in Biomedical …, 2022 - iopscience.iop.org
Recording from a large neuronal population of neurons is a crucial challenge to unravel how
information is processed by the brain. In this review, we highlight the recent advances made …

Electrophysiological phenotype characterization of human iPSC‐derived neuronal cell lines by means of high‐density microelectrode arrays

S Ronchi, AP Buccino, G Prack, SS Kumar… - Advanced …, 2021 - Wiley Online Library
Recent advances in the field of cellular reprogramming have opened a route to studying the
fundamental mechanisms underlying common neurological disorders. High‐density …