Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
Nitrogen-containing heterocycles as anticancer agents: An overview
Background: Cancer is spreading all over the world, and it is becoming the leading cause of
major deaths. Today's most difficult task for every researcher is to invent a new drug that can …
major deaths. Today's most difficult task for every researcher is to invent a new drug that can …
Recent advances (2015–2016) in anticancer hybrids
In spite of the development of a large number of novel anticancer drugs over the years,
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …
Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel …
Some metabolic enzyme inhibitors can be used in the treatment of many diseases.
Therefore, synthesis and determination of alternative inhibitors are essential. In this study …
Therefore, synthesis and determination of alternative inhibitors are essential. In this study …
A review on recent approaches on molecular docking studies of novel compounds targeting acetylcholinesterase in Alzheimer disease
SC Peitzika, E Pontiki - Molecules, 2023 - mdpi.com
Alzheimer's disease (AD), a neurodegenerative brain disorder that affects millions of people
worldwide, is characterized by memory loss and cognitive decline. Low levels of …
worldwide, is characterized by memory loss and cognitive decline. Low levels of …
Therapeutic evolution of benzimidazole derivatives in the last quinquennial period
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
1, 3, 5‐Triazine: A versatile pharmacophore with diverse biological activities
S Singh, MK Mandal, A Masih, A Saha… - Archiv der …, 2021 - Wiley Online Library
Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to
their effective biological activities, such as antibacterial, fungicidal, antimalarial, anticancer …
their effective biological activities, such as antibacterial, fungicidal, antimalarial, anticancer …
Benzimidazole scaffold as anticancer agent: synthetic approaches and structure–activity relationship
Cancer, also known as malignant neoplasm, is a dreadful disease which involves abnormal
cell growth having the potential to invade or spread to other parts of the body …
cell growth having the potential to invade or spread to other parts of the body …
1, 3, 5-Triazines: A promising scaffold for anticancer drugs development
S Cascioferro, B Parrino, V Spanò, A Carbone… - European journal of …, 2017 - Elsevier
This review covering literature reports from the beginning of this century to 2016 describes
the synthetic pathways, the antitumor activity, the structure-activity relationship and …
the synthetic pathways, the antitumor activity, the structure-activity relationship and …
Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail …
HO Tawfik, A Petreni, CT Supuran… - European journal of …, 2022 - Elsevier
The hydrophobic and the hydrophilic rims in the active site of human carbonic anhydrase IX
(hCA IX) which as well contains a zinc ion as part of the catalytic core, were simultaneously …
(hCA IX) which as well contains a zinc ion as part of the catalytic core, were simultaneously …