Chemiluminescent spiroadamantane-1, 2-dioxetanes: Recent advances in molecular imaging and biomarker detection

HN Kagalwala, RT Reeves, AR Lippert - Current opinion in chemical …, 2022 - Elsevier
Triggered chemiluminescence emission of spiroadamantane-1, 2-dioxetanes to detect
bioanalytes has fueled the emerging popularity of chemiluminescence imaging in live …

Exploring the structural space of chemiluminescent 1, 2-dioxetanes

U Haris, AR Lippert - ACS sensors, 2022 - ACS Publications
Chemiluminescent molecules which emit light in response to a chemical reaction are
powerful tools for the detection and measurement of biological analytes and enable the …

Bioorthogonal masked acylating agents for proximity-dependent RNA labelling

S Pani, T Qiu, K Kentala, SA Azizi, BC Dickinson - Nature Chemistry, 2024 - nature.com
RNA localization is highly regulated, with subcellular organization driving context-
dependent cell physiology. Although proximity-based labelling technologies that use highly …

Seeking Illumination: The Path to Chemiluminescent 1,2-Dioxetanes for Quantitative Measurements and In Vivo Imaging

U Haris, HN Kagalwala, YL Kim… - Accounts of chemical …, 2021 - ACS Publications
Conspectus Chemiluminescence is a fascinating phenomenon that evolved in nature and
has been harnessed by chemists in diverse ways to improve life. This Account tells the story …

Computation-guided optimization of split protein systems

TB Dolberg, AT Meger, JD Boucher… - Nature chemical …, 2021 - nature.com
Splitting bioactive proteins into conditionally reconstituting fragments is a powerful strategy
for building tools to study and control biological systems. However, split proteins often …

Six‐Membered Aromatic Nitrogen Heterocyclic Anti‐Tumor Agents: Synthesis and Applications

J Li, A Gu, XM Nong, S Zhai, ZY Yue… - The Chemical …, 2023 - Wiley Online Library
Cancer stands as a serious malady, posing substantial risks to human well‐being and
survival. This underscores the paramount necessity to explore and investigate novel …

B12-induced reassembly of split photoreceptor protein enables photoresponsive hydrogels with tunable mechanics

Z Yang, HKF Fok, J Luo, Y Yang, R Wang, X Huang… - Science …, 2022 - science.org
Although the tools based on split proteins have found broad applications, ranging from
controlled biological signaling to advanced molecular architectures, many of them suffer …

Evaluation of cell viability with a single fluorescent probe based on two kinds of fluorescence signal modes

Y Lai, T Zhang, W Song, Z Li, W Lin - Analytical Chemistry, 2021 - ACS Publications
Accurate evaluation of cell viability is important for dosage tests of anticancer drugs,
pathology, and numerous biological experiments. However, due to the serious insufficieny of …

Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression

HK Jiang, NL Ambrose, CZ Chung… - Proceedings of the …, 2023 - National Acad Sciences
Synthetic biology tools for regulating gene expression have many useful biotechnology and
therapeutic applications. Most tools developed for this purpose control gene expression at …

Phage-assisted continuous evolution and selection of enzymes for chemical synthesis

KA Jones, HM Snodgrass, K Belsare… - ACS Central …, 2021 - ACS Publications
Ligand-dependent biosensors are valuable tools for coupling the intracellular
concentrations of small molecules to easily detectable readouts such as absorbance …