Shared signaling pathways in Alzheimer's and metabolic disease may point to new treatment approaches
'A peculiar severe disease process of the cerebral cortex'are the exact words used by A.
Alzheimer in 1906 to describe a patient's increasingly severe condition of memory loss …
Alzheimer in 1906 to describe a patient's increasingly severe condition of memory loss …
Using Optogenetics to Model Cellular Effects of Alzheimer's Disease
P Tiwari, NS Tolwinski - International Journal of Molecular Sciences, 2023 - mdpi.com
Across the world a dementia case is diagnosed every three seconds. Alzheimer's disease
(AD) causes 50–60% of these cases. The most prominent theory for AD correlates the …
(AD) causes 50–60% of these cases. The most prominent theory for AD correlates the …
Wnt signaling rescues amyloid beta-induced gut stem cell loss
Patients with Alzheimer's disease suffer from a decrease in brain mass and a prevalence of
amyloid-β plaques. These plaques are thought to play a role in disease progression, but …
amyloid-β plaques. These plaques are thought to play a role in disease progression, but …
A kinase translocation reporter reveals real-time dynamics of ERK activity in Drosophila
AC Yuen, AR Prasad, VM Fernandes… - Biology Open, 2022 - journals.biologists.com
Extracellular signal-regulated kinase (ERK) lies downstream of a core signalling cascade
that controls all aspects of development and adult homeostasis. Recent developments have …
that controls all aspects of development and adult homeostasis. Recent developments have …
Use of optogenetic amyloid-β to monitor protein aggregation in drosophila melanogaster, danio rerio and caenorhabditis elegans
Alzheimer's Disease (AD) has long been associated with accumulation of extracellular
amyloid plaques (Aβ) originating from the Amyloid Precursor Protein. Plaques have …
amyloid plaques (Aβ) originating from the Amyloid Precursor Protein. Plaques have …
Light-activated receptor tyrosine kinases: Designs and applications
SH Crossman, H Janovjak - Current Opinion in Pharmacology, 2022 - Elsevier
Receptor tyrosine kinases (RTKs) are a large and essential membrane receptor family. The
molecular mechanisms and physiological consequences of RTK activation depend on, for …
molecular mechanisms and physiological consequences of RTK activation depend on, for …
Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease
A Ingles-Prieto, N Furthmann, SH Crossman… - PLoS …, 2021 - journals.plos.org
Optogenetics has been harnessed to shed new mechanistic light on current and future
therapeutic strategies. This has been to date achieved by the regulation of ion flow and …
therapeutic strategies. This has been to date achieved by the regulation of ion flow and …
Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice
T Rauschendorfer, S Gurri, I Heggli… - Life Science …, 2021 - life-science-alliance.org
FGFs and their high-affinity receptors (FGFRs) play key roles in development, tissue repair,
and disease. Because FGFRs bind overlapping sets of ligands, their individual functions …
and disease. Because FGFRs bind overlapping sets of ligands, their individual functions …
Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions
Dynamic protein-protein interactions are essential for proper cell functioning. Homo-
interaction events—physical interactions between the same type of proteins—represent a …
interaction events—physical interactions between the same type of proteins—represent a …
Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila
Many organs and tissues have an intrinsic ability to regenerate from a dedicated, tissue-
specific stem cell pool. As organisms age, the process of self-regulation or homeostasis …
specific stem cell pool. As organisms age, the process of self-regulation or homeostasis …