Members of the AAA+ protein superfamily contribute to many diverse aspects of protein
homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic …

Intra-plastid proteolysis is essential in plastid biogenesis, differentiation and plastid protein
homeostasis (proteostasis). We provide a comprehensive review of the Clp protease system …

Mycobacterium tuberculosis (Mtb) contains two clpP genes, both of which are essential for
viability. We expressed and purified Mtb ClpP1 and ClpP2 separately. Although each formed …

Intra-plastid proteases play crucial and diverse roles in the development and maintenance
of non-photosynthetic plastids and chloroplasts. Formation and maintenance of a functional …

Intracellular proteolysis is a tightly regulated process responsible for the targeted removal of
unwanted or damaged proteins. The non-lysosomal removal of these proteins is performed …

Tuberculosis, caused by Mycobacterium tuberculosis, still remains a major global health
problem. The main obstacle in eradicating this disease is the ability of this pathogen to …

The Clp protease system is a promising, noncanonical drug target against Mycobacterium
tuberculosis (Mtb). Unlike in Escherichia coli, the Mtb Clp protease consists of two distinct …

The N‐end rule pathway is a highly conserved process that operates in many different
organisms. It relates the metabolic stability of a protein to its N‐terminal amino acid …

Eukaryotic cells represent an intricate collaboration between multiple genomes, even down
to the level of multi‐subunit complexes in mitochondria and plastids. One such complex in …

Toxin–antitoxin systems are widely distributed among many bacterial species, including
human pathogens. Typically, these systems consist of two genes in an operon which …