Eosinophilic and noneosinophilic asthma
The term “eosinophilic” asthma (EA) generally refers to the clinical inflammatory phenotype
of asthma wherein a significant number of sputum, airway, and/or blood eosinophils are …
of asthma wherein a significant number of sputum, airway, and/or blood eosinophils are …
The biology of eosinophils and their role in asthma
CN McBrien, A Menzies-Gow - Frontiers in medicine, 2017 - frontiersin.org
This review will describe the structure and function of the eosinophil. The roles of several
relevant cell surface molecules and receptors will be discussed. We will also explore the …
relevant cell surface molecules and receptors will be discussed. We will also explore the …
Nitric oxide production and signaling in inflammation
R Korhonen, A Lahti, H Kankaanranta… - Current Drug Targets …, 2005 - ingentaconnect.com
Nitric oxide (NO) is recognized as a mediator and regulator of inflammatory responses. It
possesses cytotoxic properties that are aimed against pathogenic microbes, but it can also …
possesses cytotoxic properties that are aimed against pathogenic microbes, but it can also …
Eosinophils: biological properties and role in health and disease
SP Hogan, HF Rosenberg, R Moqbel… - Clinical & …, 2008 - Wiley Online Library
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …
Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans
Eosinophils release their granule proteins extracellularly through exocytosis, piecemeal
degranulation, or cytolytic degranulation. Findings in diverse human eosinophilic diseases …
degranulation, or cytolytic degranulation. Findings in diverse human eosinophilic diseases …
Voltage-gated proton channels and other proton transfer pathways
TE Decoursey - Physiological reviews, 2003 - journals.physiology.org
Proton channels exist in a wide variety of membrane proteins where they transport protons
rapidly and efficiently. Usually the proton pathway is formed mainly by water molecules …
rapidly and efficiently. Usually the proton pathway is formed mainly by water molecules …
Molecular mechanisms of glucocorticoid action: what is important?
R Newton - Thorax, 2000 - thorax.bmj.com
Inflammatory diseases such as asthma and rheumatoid arthritis are characterised at the
molecular level by chronically increased expression of multiple cytokines, chemokines …
molecular level by chronically increased expression of multiple cytokines, chemokines …
The eosinophil in infection
KA Ravin, M Loy - Clinical reviews in allergy & immunology, 2016 - Springer
Abstract First described by Paul Ehrlich in 1879, who noted its characteristic staining by
acidophilic dyes, for many years, the eosinophil was considered to be an end-effector cell …
acidophilic dyes, for many years, the eosinophil was considered to be an end-effector cell …
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
The molecular mechanism for the anti-inflammatory action of theophylline is currently
unknown, but low-dose theophylline is an effective add-on therapy to corticosteroids in …
unknown, but low-dose theophylline is an effective add-on therapy to corticosteroids in …