In less than 6 months, the severe acute respiratory syndrome‐coronavirus type 2 (SARS‐
CoV‐2) has spread worldwide infecting nearly 6 million people and killing over 350,000 …

Acute flaccid myelitis (AFM) is a disabling, polio-like illness mainly affecting children.
Outbreaks of AFM have occurred across multiple global regions since 2012, and the disease …

Abstract Since 2012, the United States of America has experienced a biennial spike in
pediatric acute flaccid myelitis (AFM),,,,–. Epidemiologic evidence suggests non-polio …

Neuromyelitis Optica Spectrum Disorder (NMOSD) is an inflammatory demyelinating
disease of the central nervous system (CNS) primarily affecting the optic nerves and spinal …

Metagenomic next-generation sequencing is a novel diagnostic test with the potential to
revolutionize the diagnosis of pediatric meningitis and encephalitis through unbiased …

Serodiagnosis of SARS-CoV-2 infection is impeded by immunological cross-reactivity
among the human coronaviruses (HCoVs): SARS-CoV-2, SARS-CoV-1, MERS-CoV, OC43 …

Enterovirus D68 (EV-D68) is an RNA virus that causes respiratory illnesses mainly in
children. In severe cases, it can lead to neurological complications such as acute flaccid …

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multi-system
disease whose etiological basis has not been established. Enteroviruses (EVs) as a cause …

There is a need in clinical microbiology and public health for assays that enable sensitive
and rapid detection of infectious agents. Next Generation Sequencing (NGS) is increasingly …

Current methods for detecting infections either require a sample collected from an actively
infected site, are limited in the number of agents they can query, and/or yield no information …