Maternal serum cytokine concentrations in healthy pregnancy and preeclampsia

T Spence, PJ Allsopp, AJ Yeates… - Journal of …, 2021 - Wiley Online Library
The maternal immune response is essential for successful pregnancy, promoting immune
tolerance to the fetus while maintaining innate and adaptive immunity. Uncontrolled …

Gestational diabetes mellitus and maternal immune dysregulation: what we know so far

CJ McElwain, FP McCarthy, CM McCarthy - International Journal of …, 2021 - mdpi.com
Gestational diabetes mellitus (GDM) is an obstetric complication that affects approximately 5–
10% of all pregnancies worldwide. GDM is defined as any degree of glucose intolerance …

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

GB Choi, YS Yim, H Wong, S Kim, H Kim, SV Kim… - Science, 2016 - science.org
Viral infection during pregnancy has been correlated with increased frequency of autism
spectrum disorder (ASD) in offspring. This observation has been modeled in rodents …

TH17 cells in human recurrent pregnancy loss and pre-eclampsia

B Fu, Z Tian, H Wei - Cellular & molecular immunology, 2014 - nature.com
Abstract T helper 17 (TH17) cells have been identified as a new lineage of helper T cells
and have been shown to be important in host defense against extracellular infectious …

Fetal sex‐based differences in maternal hormones, angiogenic factors, and immune mediators during pregnancy and the postpartum period

EAL Enninga, WK Nevala, DJ Creedon… - American journal of …, 2015 - Wiley Online Library
Problem Several pregnancy complications have disparities based on the sex of the fetus. It
is unknown whether the sex of the fetus differentially alters the maternal immune milieu …

Modulatory effect of intravenous immunoglobulin on Th17/Treg cell balance in women with unexplained recurrent spontaneous abortion

KP Muyayalo, ZH Li, G Mor… - American Journal of …, 2018 - Wiley Online Library
Recurrent spontaneous abortion (RSA) is a growing problem worldwide. In a majority of
cases, the cause remains unknown but there is increasing evidence that immunologic …

Extracellular vesicles in host-pathogen interactions and immune regulation—exosomes as emerging actors in the immunological theater of pregnancy

V de Lima Kaminski, JH Ellwanger, JAB Chies - Heliyon, 2019 - cell.com
This review correlates and summarizes the role of the maternal-fetal interface in the immune
tolerance of the fetus and the processes that lead to infection avoidance, emphasizing the …

The role of interleukins in preeclampsia: a comprehensive review

I Bellos, V Karageorgiou, D Kapnias… - American Journal of …, 2018 - Wiley Online Library
Preeclampsia is a multi‐system hypertensive disorder of pregnancy, with significant rates of
maternal and neonatal morbidity. It represents a major cause of preterm birth, as definitive …

Stage of gestation at porcine epidemic diarrhea virus infection of pregnant swine impacts maternal immunity and lactogenic immune protection of neonatal suckling …

SN Langel, FC Paim, MA Alhamo, A Buckley… - Frontiers in …, 2019 - frontiersin.org
During pregnancy, the maternal immune response changes dramatically over the course of
gestation. This has implications for generation of lactogenic immunity and subsequent …

Increased circulating interleukin-17 levels in preeclampsia

A Molvarec, I Czegle, J Szijártó, J Rigó Jr - Journal of reproductive …, 2015 - Elsevier
Increasing evidence suggests that an exaggerated maternal systemic inflammatory
response and an angiogenic imbalance might play a central role in the pathogenesis of …