Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …

Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

Type I and type II interferons (IFN) are central to both combating virus infection and
modulating the antiviral immune response. Indeed, an absence of either the receptor for type …

Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Enhanced glucose uptake and a switch to glycolysis are key traits of M1 macrophages,
whereas enhanced fatty acid oxidation and oxidative phosphorylation are the main …

Spaceflight is known to impose changes on human physiology with unknown molecular
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …

The risk of chronic diseases caused by aging is reduced by caloric restriction (CR)-induced
immunometabolic adaptation. Here, we found that the matricellular protein, secreted protein …

Nitric Oxide (NO) is a soluble endogenous gas with various biological functions like
signaling, and working as an effector molecule or metabolic regulator. In response to …

Macrophages, the central mediators of innate immune responses, being in the first-line of
defense, they have to readily respond to pathogenic or tissue damage signals to initiate the …