For many years the mammalian CNS has been seen as an organ that is unable to
regenerate. However, it was also long known that lower vertebrate species are capable of …

Neurofilaments (NF) are the most abundant cytoskeletal component of large myelinated
axons from adult central and peripheral nervous system. Here, we provide an overview of …

Adult mammalian CNS neurons do not normally regenerate their severed axons. This failure
has been attributed to scar tissue and inhibitory molecules at the injury site that block the …

Severed axons in adult mammals do not regenerate appreciably after central nervous
system (CNS) injury due to developmentally determined reductions in neuron-intrinsic …

Axotomized motoneurons regenerate their axons regardless of whether axotomy occurs
proximally or distally from their cell bodies. In contrast, regeneration of rubrospinal axons …

Dysfunction of surviving axons which traverse the site of spinal cord injury (SCI) appears to
contribute to posttraumatic neurological deficits, though the underlying mechanisms remain …

Studies in mice and humans have elucidated an important role for Tregs in promoting tissue
repair and restoring tissue integrity. Emerging evidence has revealed that Tregs promoted …

In mammals, spinal cord injury (SCI) leads to dramatic losses in neurons and synaptic
connections, and consequently function. Unlike mammals, lampreys are vertebrates that …

We analyzed changes in the expression of mRNAs for the axonal growth-promoting cell
recognition molecules L1. 1, L1. 2, and neural cell adhesion molecule (NCAM) after a rostral …

Among the advantages offered by the lamprey brainstem and spinal cord for studies of the
structure and function of the nervous system is the unique identifiability of several pairs of …