Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (eg,
phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl …

Drug transporters can govern the absorption, distribution, metabolism, and excretion of
substrate drugs and endogenous substances. Investigations to examine their potential …

Ethnopharmacological relevance Stroke is one of the leading causes of death and disability.
The only FDA-approved therapy for treating stroke is tissue plasminogen activator (tPA) …

Atherosclerosis is a leading cause of major vascular events, myocardial infarction, and
ischemic stroke. Tryptophan (TRP) catabolism was recognized as an important player in …

Imbalanced one carbon metabolism and aberrant autophagy is robustly reported in patients
with autism. Polymorphism in the gene methylenetetrahydrofolate reductase (Mthfr) …

Maternal dietary levels of one-carbon (1C) metabolites (folic acid and choline) during
pregnancy play a vital role in neurodevelopment. However, the impact of maternal dietary …

Adequate maternal dietary levels of one-carbon metabolites, such as folic acid and choline,
play an important role in the closure of the neural tube in utero; however, the impact of …

Background Choline and betaine have been suggested to play a pivotal role in
neurotransmitter synthesis, cell membrane integrity, and methyl-group metabolism, exerting …

Recent studies revealed that folic acid deficiency (FD) increased the likelihood of stroke and
aggravated brain injury after focal cerebral ischaemia. The microglia‐mediated inflammatory …

Most neurodegenerative diseases, such as Alzheimer's and Parkinson's disease,
demonstrate preceding or on-going inflammatory processes. Therefore, discovering effective …