Stem cells are continuously challenged with the decision to either self-renew or adopt a new
fate. Self-renewal is regulated by a system of cellular memory, which must be bypassed for …

Resistance to radiotherapy (IR), with consequent disease recurrence, continues to limit the
efficacy of contemporary anticancer treatment for patients with hepatocellular carcinoma …

Human developmental disorders encompass a wide range of debilitating physical
conditions and intellectual disabilities. Perturbation of protein kinase signalling underlies the …

AKT/PKB is a kinase crucial for pluripotency maintenance in pluripotent stem cells. Multiple
post-translational modifications modulate its activity. We have previously demonstrated that …

Colon cancer has been proposed to be sustained by a small subpopulation of stem-like cells
with unique properties allowing them to survive conventional therapies and drive tumor …

Vasculogenic mimicry (VM), which involved the formation of vascular-like structures by
highly invasive tumor cells, had been identified as one of the mechanisms contributing to …

Protein kinases modulate the reversible postmodifications of substrate proteins to their
phosphorylated forms as an essential process in regulating intracellular signaling …

AKT/PKB is a kinase involved in the regulation of a plethora of cell processes. Particularly, in
embryonic stem cells (ESCs), AKT is crucial for the maintenance of pluripotency. Although …

Differentiated multipotent pancreatic progenitors have major advantages for both modeling
pancreas development and preventing or treating diabetes. Despite significant …

The ERK5 MAP kinase signalling pathway drives transcription of naïve pluripotency genes
in mouse Embryonic Stem Cells (mESCs). However, how ERK5 impacts on other aspects of …