Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …

In developmental biology, knowledge of cell structure and their (morpho) dynamic behavior,
leads to a comprehensive understanding of their conducts and the mechanisms in which …

Deciphering the mechanisms that regulate the quiescence of adult neural stem cells (NSCs)
is crucial for the development of therapeutic strategies based on the stimulation of their …

Although neural stem cells (NSCs) sustain continuous neurogenesis throughout the adult
lifespan of mammals, they progressively exhibit proliferation defects that contribute to a …

The generation of new neurons is a lifelong process in many vertebrate species that
provides an extra level of plasticity to several brain circuits. Frequently, neurogenesis in the …

Identifying the mechanisms controlling quiescence and activation of neural stem cells
(NSCs) is crucial for understanding brain repair. Here, we demonstrate that Hedgehog (Hh) …

Individual cells dissected from the subependymal neurogenic niche of the adult mouse brain
proliferate in medium containing basic fibroblast growth factor (bFGF) and/or epidermal …

Neural stem cell activity in the ventricular-subventricular zone (V-SVZ) decreases with aging,
thought to occur by a unidirectional decline. However, by analyzing the V-SVZ transcriptome …

Background The origin and classification of neural stem cells (NSCs) has been a subject of
intense investigation for the past two decades. Efforts to categorize NSCs based on their …

Neural stem cell (NSC) cultures have been considered technically challenging for time-
lapse analysis due to high motility, photosensitivity, and growth at confluent densities. We …