The human skeleton has remarkable regenerative properties, being one of the few
structures in the body that can heal by recreating its normal cellular composition, orientation …

Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …

Large bone defects cannot form a callus and exhibit high complication rates even with the
best treatment strategies available. Tissue engineering approaches often use scaffolds …

The biomechanical environment plays a dominant role in the process of fracture repair.
Mechanical signals control biological activities at the fracture site, regulate the formation and …

In order to achieve consistent and predictable fracture healing, a broad spectrum of growth
factors are required to interact with one another in a highly organized response. Critically …

Despite its natural healing potential, bone is unable to regenerate sufficient tissue within
critical‐sized defects, resulting in a non‐union of bone ends. As a consequence …

In vitro assays can be useful in determining biological mechanism and optimizing scaffold
parameters, however translation of the in vitro results to clinics is generally hard. Animal …

Despite the high innate regenerative capacity of bone, large osseous defects fail to heal and
remain a clinical challenge. Healing such defects requires the formation of large amounts of …

The regeneration of bone in segmental defects has historically been a challenge in the
orthopedic field. In particular, a lack of vascular supply often leads to nonunion and …

Orthopedic injuries are common and a source of much misery and economic stress. Several
relevant tissues, such as cartilage, meniscus, and intra-articular ligaments, do not heal. And …