The biomechanics of subsynovial connective tissue in health and its role in carpal tunnel syndrome

V Festen-Schrier, PC Amadio - Journal of electromyography and …, 2018 - Elsevier
Abstract Carpal Tunnel Syndrome (CTS) is the most common surgically treated problem in
the hand. Aside from the neuropathy itself, the most common findings are fibrosis of the …

Clinical evidence and mechanisms of growth factors in idiopathic and diabetes-induced carpal tunnel syndrome

D Sharma, AS Jaggi, A Bali - European journal of pharmacology, 2018 - Elsevier
Carpal tunnel syndrome (CTS) is an entrapment neuropathy caused by compression and
irritation of the median nerve, which travels through the carpal tunnel in the wrist. Increased …

A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome

A Wiberg, M Ng, AB Schmid, RW Smillie… - Nature …, 2019 - nature.com
Carpal tunnel syndrome (CTS) is a common and disabling condition of the hand caused by
entrapment of the median nerve at the level of the wrist. It is the commonest entrapment …

Platelet-rich plasma versus corticosteroid injections for carpal tunnel syndrome

H Uzun, O Bitik, Ö Uzun, US Ersoy… - Journal of Plastic Surgery …, 2017 - Taylor & Francis
Background: Platelet-rich plasma therapy has the potential to promote peripheral nerve
regeneration through the autologous supply of growth factors. Therefore, this study aimed to …

Manual therapy prevents onset of nociceptor activity, sensorimotor dysfunction, and neural fibrosis induced by a volitional repetitive task

GM Bove, SP Delany, L Hobson, GE Cruz, MY Harris… - Pain, 2019 - journals.lww.com
Painful and disabling musculoskeletal disorders remain prevalent. In rats trained to perform
repetitive tasks leading to signs and dysfunction similar to those in humans, we tested …

Systemic inflammatory markers in neuropathic pain, nerve injury, and recovery

O Sandy-Hindmarch, DL Bennett, A Wiberg, D Furniss… - Pain, 2022 - journals.lww.com
The role that inflammation plays in human nerve injury and neuropathic pain is incompletely
understood. Previous studies highlight the role of inflammation in the generation and …

Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury

GM Bove, MY Harris, H Zhao, MF Barbe - Journal of the neurological …, 2016 - Elsevier
Key clinical features of carpal tunnel syndrome and other types of cumulative trauma
disorders of the hand and wrist include pain and functional disabilities. Mechanistic details …

Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury

PW Fisher, Y Zhao, MC Rico, VS Massicotte… - Journal of cell …, 2015 - Springer
Key clinical features of cumulative trauma disorders include pain, muscle weakness, and
tissue fibrosis, although the etiology is still under investigation. Here, we characterized the …

TGF‐β signaling regulates fibrotic expression and activity in carpal tunnel syndrome

A Gingery, TH Yang, SM Passe, KN An… - Journal of …, 2014 - Wiley Online Library
Fibrosis of the subsynovial connective tissue (SSCT) is a predominant feature of carpal
tunnel syndrome (CTS). While the nature of CTS has been extensively studied, little is …

Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse‐induced median mononeuropathy

MF Barbe, BA Hilliard, M Amin… - Journal of …, 2020 - Wiley Online Library
Encapsulation of median nerves is a hallmark of overuse‐induced median mononeuropathy
and contributes to functional declines. We tested if an antibody against CTGF/CCN2 (termed …