This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …

Protein aggregation is common to dozens of diseases including prionoses, diabetes,
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …

Alteration of mitochondria-associated membranes (MAMs) has been proposed to contribute
to the pathogenesis of Alzheimer's disease (AD). We studied herein the subcellular …

A hallmark of Alzheimer disease (AD) is the accumulation of the amyloid-β (Aβ) peptide in
the brain. Considerable evidence suggests that soluble Aβ oligomers are responsible for the …

Amyloid-β oligomers (AβOs) are the most important toxic species in the brain of Alzheimer's
disease (AD) patient. AβOs, therefore, are considered reliable molecular biomarkers for the …

Ceruloplasmin is a ferroxidase that interacts with ferroportin to export cellular iron, but is not
expressed in neurons. We recently reported that the amyloid precursor protein (APP) is the …

Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer's disease
(AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and …

Alzheimer's disease is the most common form of dementia and the generation of oligomeric
species of amyloid-β is causal to the initiation and progression of it. Amyloid-β oligomers …

Beta-amyloid (Aβ) peptides are the major constituents of senile plaques in the brains of
Alzheimer's disease (AD) patients. Aβ monomers (AβMs) can coalesce to form small, soluble …

The prion protein (PrPC) is a central player in neurodegenerative diseases, such as prion
diseases or Alzheimer's disease. In contrast to disease-promoting cell surface PrPC …