Introduction• Spermatogonial stem cells‐Regulation of SSC maintenance and differentiation‐
SSC culture, transplantation and plasticity• SSC in infertility• SSC in testicular germ cell …

In testicular germ cell tumor type II (TGCT), a seminoma subtype expresses an induced
pluripotent stem cell (iPSC) panel with four upregulated genes, OCT4/POU5F1, SOX17 …

Spermatogonial stem cells (SSCs) maintain spermatogenesis by self-renewal and
generation of spermatogonia committed to differentiation. Under certain in vitro conditions …

Germ cell cancers are the most common solid tumors among men between 15 and 40 years.
With a worldwide incidence of 70,000, germ cell cancers account for 1% of the male tumors …

Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor critically involved in cell
proliferation, differentiation, and carcinogenesis. Recently, KLF4 was also used for the …

There is no consensus as to how a precursor lesion, germ cell neoplasia in situ (GCNIS),
develops into the histologic types of testicular germ cell tumor type II (TGCT). The present …

Krüppel-like factor 4 (Klf4, GKLF) was originally characterized as a zinc finger transcription
factor essential for terminal differentiation and cell lineage allocation of several cell types in …

Krüppel-like factor 4 (KLF4) is a kind of zinc finger transcription factor, which is involved in
terminal differentiation of epithelial cells and reprogramming of somatic cells to induced …

There has been great progress in the understanding of the molecular events involved in
normal germ cell maturation and testicular tumour pathobiology. Identification of the …

哺乳动物多能性因子, 主要包括Pou5f1/Oct4, Sox2, Klf4, Nanog 等转录因子, 不仅能够维持胚胎
干细胞的未分化状态, 同时也参与使分化细胞重编程回多能性状态的过程 …