Stem cells applications in regenerative medicine and disease therapeutics

RS Mahla - International journal of cell biology, 2016 - Wiley Online Library
Regenerative medicine, the most recent and emerging branch of medical science, deals
with functional restoration of tissues or organs for the patient suffering from severe injuries or …

Concise review: amniotic fluid stem cells: the known, the unknown, and potential regenerative medicine applications

SP Loukogeorgakis, P De Coppi - Stem Cells, 2017 - academic.oup.com
The amniotic fluid has been identified as an untapped source of cells with broad potential,
which possess immunomodulatory properties and do not have the ethical and legal …

HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1–3 and PKM2

A Prigione, N Rohwer, S Hoffmann, B Mlody… - Stem …, 2014 - academic.oup.com
Reprogramming somatic cells to a pluripotent state drastically reconfigures the cellular
anabolic requirements, thus potentially inducing cancer-like metabolic transformation …

Perinatal derivatives: where do we stand? A roadmap of the human placenta and consensus for tissue and cell nomenclature

AR Silini, R Di Pietro, I Lang-Olip, F Alviano… - … in bioengineering and …, 2020 - frontiersin.org
Progress in the understanding of the biology of perinatal tissues has contributed to the
breakthrough revelation of the therapeutic effects of perinatal derivatives (PnD), namely birth …

Mesenchymal stem/stromal cells derived from human and animal perinatal tissues—origins, characteristics, signaling pathways, and clinical trials

M Kulus, R Sibiak, K Stefańska, M Zdun… - Cells, 2021 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) are currently one of the most extensively
researched fields due to their promising opportunity for use in regenerative medicine. There …

Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells

K Wuputra, CC Ku, DC Wu, YC Lin, S Saito… - Journal of Experimental …, 2020 - Springer
Human pluripotent embryonic stem cells have two special features: self-renewal and
pluripotency. It is important to understand the properties of pluripotent stem cells and …

Amniotic fluid and amniotic membrane stem cells: marker discovery

MG Roubelakis, O Trohatou… - Stem cells …, 2012 - Wiley Online Library
Amniotic fluid (AF) and amniotic membrane (AM) have been recently characterized as
promising sources of stem or progenitor cells. Both not only contain subpopulations with …

Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell–like …

A Prigione, B Lichtner, H Kuhl, EA Struys… - Stem …, 2011 - academic.oup.com
Human induced pluripotent stem cells (iPSCs) have been recently found to harbor genomic
alterations. However, the integrity of mitochondrial DNA (mtDNA) within reprogrammed cells …

Stem cell insights into human trophoblast lineage differentiation

TKJB Gamage, LW Chamley… - Human reproduction …, 2017 - academic.oup.com
BACKGROUND The human placenta is vital for fetal development, yet little is understood
about how it forms successfully to ensure a healthy pregnancy or why this process is …

Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations

A Prigione, AM Hossini, B Lichtner, A Serin, B Fauler… - PloS one, 2011 - journals.plos.org
Somatic cells reprogrammed into induced pluripotent stem cells (iPSCs) acquire features of
human embryonic stem cells (hESCs) and thus represent a promising source for cellular …