RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Background Recent assays for individual-specific genome-wide DNA methylation profiles
have enabled epigenome-wide association studies to identify specific CpG sites associated …

The Runt‐related transcription factors (RUNX) belong to an ancient family of metazoan
genes involved in developmental processes. Through multiple protein‐interacting partners …

The three mammalian Runt homology domain transcription factors (Runx1, Runx2, Runx3)
support biological control by functioning as master regulatory genes for the differentiation of …

Background The RUNX family of transcription factors plays an important regulatory role in
tumor development. Although the importance of RUNX in certain cancer types is well known …

Individual age estimation is a key factor in forensic science analysis that can provide very
useful information applicable to criminal, legal, and anthropological investigations. Forensic …

To better understand the biology of hormone receptor–positive and–negative breast cancer
and to identify methylated gene markers of disease progression, we carried out a genome …

Runx proteins (also known as Runt-domain transcription factors) have been studied for a
long time as key regulators of cellular differentiation. RUNX2 has been described as …

Breast cancer is the fifth cause of cancer death among women worldwide and represents a
global health concern due to the lack of effective therapeutic regimens that could be applied …