Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

Six different types of cancer (ie, breast, lung, colorectal, esophageal, gastric and thyroid
cancer) have high rates of incidence or mortality worldwide. It has been shown that …

Despite advances in clinical diagnosis and treatment, the prognosis of patients with
osteosarcoma (OS) remains poor, and the treatment efficacy has plateaued. Therefore, it is …

Transforming growth factor-beta (TGF-β) is a member of a family of secreted cytokines with
vital biological functions in cells. The abnormal expression of TGF-β signaling is a common …

The hippocampus is a heterogeneous structure, comprising histologically distinguishable
subfields. These subfields are differentially involved in memory consolidation, spatial …

Proteasome activator subunit 3 (REGγ) has a key role in breast cancer by promoting protein
proteolysis, but methods to block REGγ expression remain elusive. In this study, we found …

The Wnt pathway has emerged as a key signaling cascade participating in mammary
organogenesis and breast oncogenesis. In this review, we will summarize the current …

Cohesin shapes the chromatin architecture, including enhancer-promoter interactions. Its
components, especially STAG2, but not its paralog STAG1, are frequently mutated in …

Background Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box
domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell …