New technologies have enabled the investigation of biology and human health at an
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …

Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

Determining causal relationships between distinct chromatin features and gene expression,
and ultimately cell behavior, remains a major challenge. Recent developments in targetable …

Cells can be programmed to monitor and react to their environment using genetic circuits.
Design automation software maps a desired circuit function to a DNA sequence, a process …

Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory
elements, sequence motifs, the choice of transcription start sites and other features. Several …

The methylotrophic yeast Pichia pastoris is a widely used host for heterologous protein
production. Along with favorable properties such as growth to high cell density and high …

Transcriptional enhancers are the primary determinants of tissue-specific gene expression.
Although the majority of our current knowledge of enhancer elements comes from detailed …

Gene expression changes, the driving forces for cellular diversity in multicellular organisms,
are regulated by a diverse set of gene regulatory elements that direct transcription in specific …

With current advances in genomics, several technological processes have been generated,
resulting in improvement in different segments of molecular research involving prokaryotic …

Microalgae hold enormous potential to provide a safe and sustainable source of high-value
compounds, acting as carbon-fixing biofactories that could help to mitigate rapidly …