Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies

D Seo, DM Holtzman - Experimental & molecular medicine, 2024 - nature.com
Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease. Despite
tremendous research efforts to understand this complex disease, the exact pathophysiology …

Lipopolysaccharides (LPSs) as potent neurotoxic glycolipids in Alzheimer's disease (AD)

Y Zhao, VR Jaber, AI Pogue, NM Sharfman… - International Journal of …, 2022 - mdpi.com
Lipopolysaccharides (LPSs) are microbiome-derived glycolipids that are among the most
potent pro-inflammatory neurotoxins known. In Homo sapiens, the major sources of LPSs …

The common marmoset as a model of neurodegeneration

C Perez-Cruz, J de Dios Rodriguez-Callejas - Trends in Neurosciences, 2023 - cell.com
Human life expectancy has increased over the past few centuries, and the incidence of
dementia in the older population is also projected to continue to rise. Neurodegenerative …

The astrocyte: metabolic hub of the brain

LF Barros, S Schirmeier… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Astrocytic metabolism has taken center stage. Interposed between the neuron and the
vasculature, astrocytes exert control over the fluxes of energy and building blocks required …

Short-chain fatty acids in the microbiota–gut–brain axis: role in neurodegenerative disorders and viral infections

A Majumdar, IP Siva Venkatesh… - ACS Chemical …, 2023 - ACS Publications
The gut–brain axis (GBA) is the umbrella term to include all bidirectional communication
between the brain and gastrointestinal (GI) tract in the mammalian body. Evidence from over …

Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

YY Ma, X Li, JT Yu, YJ Wang - Translational Neurodegeneration, 2024 - Springer
The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease
(AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's …

The gut microbiota‐astrocyte axis: implications for type 2 diabetic cognitive dysfunction

ZH Li, YY Jiang, CY Long, Q Peng… - CNS Neuroscience & …, 2023 - Wiley Online Library
Background Diabetic cognitive dysfunction (DCD) is one of the most insidious complications
of type 2 diabetes mellitus, which can seriously affect the ability to self‐monitoring of blood …

Beneficial effects of butyrate on brain functions: a view of epigenetic

GCÁ Alpino, GA Pereira-Sol, MM Dias… - Critical Reviews in …, 2024 - Taylor & Francis
Brain functions are influenced by the presence, activity, and metabolism of the gut
microbiota through the gut-microbiota-brain (GMB) axis. The consumption of a fiber-rich diet …

The contribution of age-related changes in the gut-brain axis to neurological disorders

R Khan, CM Di Gesù, J Lee, LD McCullough - Gut microbes, 2024 - Taylor & Francis
Trillions of microbes live symbiotically in the host, specifically in mucosal tissues such as the
gut. Recent advances in metagenomics and metabolomics have revealed that the gut …

Controlling Gut Microbiota by Twendee X® May Contribute to Dementia Prevention

F You, Y Harakawa, T Yoshikawa… - International Journal of …, 2023 - mdpi.com
The human gut microbiota (GM) is a complex and dynamic ecosystem that hosts trillions of
commensal and potentially pathogenic microorganisms. It is crucial in protecting humans …