Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

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Clinical and epidemiological studies support a connection between obesity and thrombosis,
involving elevated expression of the prothrombotic molecules plasminogen activator …

It is now widely recognized that a strong correlation exists between cancer and aberrant
hemostasis. Patients with various types of cancers, including pancreatic, colorectal, and …

Tissue factor (TF) expression by tumor cells correlates with metastasis clinically and
supports metastasis in experimental settings. However, the precise pathways coupling TF to …

Protease-activated receptors (PARs) are G protein-coupled receptors that are activated by
proteolytical cleavage of the amino-terminus and thereby act as sensors for extracellular …

The gut microbiota is a complex ecosystem that has coevolved with host physiology.
Colonization of germ-free (GF) mice with a microbiota promotes increased vessel density in …

The tissue factor (TF) pathway plays a central role in hemostasis and thrombo‐inflammatory
diseases. Although structure‐function relationships of the TF initiation complex are …

Emerging evidence shows a broad spectrum of biological functions of tissue factor (TF). TF
classical role in initiating the extrinsic blood coagulation and its direct thrombotic action in …

Coagulation activation by tissue factor (TF) is implicated in cancer progression, cancer-
associated thrombosis and metastasis. The role of direct TF signaling pathways in cancer …