Oxalate homeostasis is maintained through a delicate balance between endogenous
sources, exogenous supply and excretion from the body. Novel studies have shed light on …

The intake of foods derived from plants has been proposed as an useful strategy in the
prevention of several chronic diseases. However, plants also possess a group of substances …

Sensing and clearance of dysfunctional lysosomes is critical for cellular homeostasis. Here
we show that transcription factor EB (TFEB)—a master transcriptional regulator of lysosomal …

Abstract The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter,
longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 …

Hyperoxaluria results from either inherited disorders of glyoxylate metabolism leading to
hepatic oxalate overproduction (primary hyperoxaluria), or increased intestinal oxalate …

Over-accumulation of oxalate in humans may lead to nephrolithiasis and nephrocalcinosis.
Humans lack endogenous oxalate degradation pathways (ODP), but intestinal microbes can …

Oxalate is both a plant-derived molecule and a terminal toxic metabolite with no known
physiological function in humans. It is predominantly eliminated by the kidneys through …

Background Primary hyperoxaluria (PH) type 3 (PH3) is caused by mutations in the hydroxy-
oxo-glutarate aldolase 1 gene. PH3 patients often present with recurrent urinary stone …

Patients with primary hyperoxaluria experience kidney stones from a young age and can
develop progressive oxalate nephropathy. Progression to kidney failure often develops over …

Epigenetic modifications (eg DNA methylation) in NAFLD and their contribution to disease
progression and extrahepatic complications are poorly explored. Here, we use an integrated …