Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

The mechanistic target of rapamycin (mTOR) signaling pathway is a crucial cellular
signaling hub that, like the nervous system itself, integrates internal and external cues to …

Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …

TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

Cellular senescence is a form of adaptive cellular physiology associated with aging. Cellular
senescence causes a proinflammatory cellular phenotype that impairs tissue regeneration …

Vertebrate myelination is an evolutionary advancement essential for motor, sensory, and
higher-order cognitive function. CNS myelin, a multilamellar differentiation of the …

Altered myelin structure and oligodendrocyte function have been shown to correlate with
cognitive and motor dysfunction and deficits in social behavior. We and others have …

Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are
lipid-rich and multilamellar membrane stacks. The lipid composition of myelin varies …

The restoration of myelin sheaths on demyelinated axons remains a major obstacle in the
treatment of multiple sclerosis (MS). Currently approved therapies work by modulating the …

Myelin is essential to nervous system function, playing roles in saltatory conduction and
trophic support. Oligodendrocytes (OLs) and Schwann cells (SCs) form myelin in the central …