Bipolar disorder

AF Carvalho, J Firth, E Vieta - New England Journal of Medicine, 2020 - Mass Medical Soc
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Bipolar disorders

E Vieta, M Berk, TG Schulze, AF Carvalho… - Nature reviews Disease …, 2018 - nature.com
Bipolar disorders are chronic and recurrent disorders that affect> 1% of the global
population. Bipolar disorders are leading causes of disability in young people as they can …

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

JY Hansen, G Shafiei, RD Markello, K Smart… - Nature …, 2022 - nature.com
Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

N Mullins, AJ Forstner, KS O'Connell, B Coombes… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Local molecular and global connectomic contributions to cross-disorder cortical abnormalities

JY Hansen, G Shafiei, JW Vogel, K Smart… - Nature …, 2022 - nature.com
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …

The genetic architecture of the human cerebral cortex

KL Grasby, N Jahanshad, JN Painter, L Colodro-Conde… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

PM Thompson, N Jahanshad, CRK Ching… - Translational …, 2020 - nature.com
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …

Mapping the heterogeneous phenotype of schizophrenia and bipolar disorder using normative models

T Wolfers, NT Doan, T Kaufmann, D Alnæs… - JAMA …, 2018 - jamanetwork.com
Importance Schizophrenia and bipolar disorder are severe and complex brain disorders
characterized by substantial clinical and biological heterogeneity. However, case-control …

Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study

CD Whelan, A Altmann, JA Botía, N Jahanshad… - Brain, 2018 - academic.oup.com
Progressive functional decline in the epilepsies is largely unexplained. We formed the
ENIGMA-Epilepsy consortium to understand factors that influence brain measures in …

Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders

MD Hettwer, S Larivière, BY Park… - Nature …, 2022 - nature.com
Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing
multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations …