Tieing together loose ends: telomere instability in cancer and aging
G Borges, M Criqui, L Harrington - Molecular oncology, 2022 - Wiley Online Library
Telomere maintenance is essential for maintaining genome integrity in both normal and
cancer cells. Without functional telomeres, chromosomes lose their protective structure and …
cancer cells. Without functional telomeres, chromosomes lose their protective structure and …
[HTML][HTML] The bridge between cell survival and cell death: reactive oxygen species-mediated cellular stress
NV Acar, RK Özgül - EXCLI journal, 2023 - ncbi.nlm.nih.gov
As a requirement of aerobic metabolism, regulation of redox homeostasis is indispensable
for the continuity of living homeostasis and life. Since the stability of the redox state is …
for the continuity of living homeostasis and life. Since the stability of the redox state is …
HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
HUWE1 is a large, enigmatic HECT-domain ubiquitin ligase implicated in the regulation of
diverse pathways, including DNA repair, apoptosis, and differentiation. How HUWE1 …
diverse pathways, including DNA repair, apoptosis, and differentiation. How HUWE1 …
A ubiquitination cascade regulating the integrated stress response and survival in carcinomas
Systematic identification of signaling pathways required for the fitness of cancer cells will
facilitate the development of new cancer therapies. We used gene essentiality …
facilitate the development of new cancer therapies. We used gene essentiality …
C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption
While the toxicity of PARP inhibitors to cells with defects in homologous recombination (HR)
is well established, other synthetic lethal interactions with PARP1/PARP2 disruption are …
is well established, other synthetic lethal interactions with PARP1/PARP2 disruption are …
The HAPSTR2 retrogene buffers stress signaling and resilience in mammals
We recently identified HAPSTR1 (C16orf72) as a key component in a novel pathway which
regulates the cellular response to molecular stressors, such as DNA damage, nutrient …
regulates the cellular response to molecular stressors, such as DNA damage, nutrient …
[HTML][HTML] Stress biology: Complexity and multifariousness in health and disease
Preserving and regulating cellular homeostasis in the light of changing environmental
conditions or developmental processes is of pivotal importance for single cellular and …
conditions or developmental processes is of pivotal importance for single cellular and …
Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life
The recently discovered HAPSTR1 protein broadly oversees cellular stress responses. This
function requires HUWE1, a ubiquitin ligase that paradoxically marks HAPSTR1 for …
function requires HUWE1, a ubiquitin ligase that paradoxically marks HAPSTR1 for …
Novel functions of a retroposed gene
I Makałowska, MR Kubiak - Trends in Genetics, 2023 - cell.com
Retroposed protein-coding genes are commonly considered to be nonfunctional duplicates.
However, they often gain transcriptional capability and have important roles. Amici et al …
However, they often gain transcriptional capability and have important roles. Amici et al …
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
Abstract Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not
only in loss of its tumor-suppressive function but also acquisition of dominant-negative and …
only in loss of its tumor-suppressive function but also acquisition of dominant-negative and …