The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

Despite its complexity, blood is probably the best understood developmental system, largely
due to seminal experimentation in the mouse. Clinically, hematopoietic stem cell (HSC) …

NPM1 is the most frequently mutated gene in cytogenetically normal acute myeloid leukemia
(AML). In AML cells, NPM1 mutations result in abnormal cytoplasmic localization of the …

Haematopoietic stem cells (HSCs) are derived early from embryonic precursors, such as
haemogenic endothelial cells and pre-haematopoietic stem cells (pre-HSCs), the molecular …

The direct lineage reprogramming of one specialized cell type into another using defined
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …

Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells
to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through …

Reconstruction of the molecular pathways controlling organ development has been
hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a …

Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

Inductive signals and transcription factors involved in motor neuron generation have been
identified, raising the question of whether these developmental insights can be used to …