Current opinion on risk assessment of cosmetics
KB Kim, SJ Kwack, JY Lee, S Kacew… - Journal of Toxicology …, 2021 - Taylor & Francis
Risk assessment of cosmetic ingredients is a useful scientific method to characterize
potential adverse effects resulting from using cosmetics. The process of risk assessment …
potential adverse effects resulting from using cosmetics. The process of risk assessment …
Chemical and biological assessments of environmental mixtures: A review of current trends, advances, and future perspectives
Considering the chemical complexity and toxicity data gaps of environmental mixtures, most
studies evaluate the chemical risk individually. However, humans are usually exposed to a …
studies evaluate the chemical risk individually. However, humans are usually exposed to a …
Risk characterization and probabilistic concentration–response modeling of complex environmental mixtures using new approach methodologies (NAMs) data from …
Background: Risk assessment of chemical mixtures or complex substances remains a major
methodological challenge due to lack of available hazard or exposure data. Therefore, risk …
methodological challenge due to lack of available hazard or exposure data. Therefore, risk …
Cardiotoxicity hazard and risk characterization of toxcast chemicals using human induced pluripotent stem cell-derived cardiomyocytes from multiple donors
SD Burnett, AD Blanchette, WA Chiu… - Chemical research in …, 2021 - ACS Publications
Heart disease remains a significant human health burden worldwide with a significant
fraction of morbidity attributable to environmental exposures. However, the extent to which …
fraction of morbidity attributable to environmental exposures. However, the extent to which …
In silico approaches in organ toxicity hazard assessment: current status and future needs in predicting liver toxicity
Hepatotoxicity is one of the most frequently observed adverse effects resulting from
exposure to a xenobiotic. For example, in pharmaceutical research and development it is …
exposure to a xenobiotic. For example, in pharmaceutical research and development it is …
High-throughput screening paradigms in ecotoxicity testing: Emerging prospects and ongoing challenges
D Wlodkowic, M Jansen - Chemosphere, 2022 - Elsevier
The rapidly increasing number of new production chemicals coupled with stringent
implementation of global chemical management programs necessities a paradigm shift …
implementation of global chemical management programs necessities a paradigm shift …
Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human-Induced …
HHD Tsai, LC Ford, SD Burnett, AN Dickey… - Chemical research in …, 2024 - ACS Publications
Environmental chemicals may contribute to the global burden of cardiovascular disease, but
experimental data are lacking to determine which substances pose the greatest risk. Human …
experimental data are lacking to determine which substances pose the greatest risk. Human …
[HTML][HTML] Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays
The application of in vitro biological assays as new approach methodologies (NAMs) to
support grouping of UVCB (unknown or variable composition, complex reaction products …
support grouping of UVCB (unknown or variable composition, complex reaction products …
Grouping of UVCB substances with new approach methodologies (NAMs) data
One of the most challenging areas in regulatory science is assessment of the substances
known as UVCB (unknown or variable composition, complex reaction products and …
known as UVCB (unknown or variable composition, complex reaction products and …
Integrating high-throughput phenotypic profiling and transcriptomic analyses to predict the hepatosteatosis effects induced by per-and polyfluoroalkyl substances
YS Luo, RY Ying, XT Chen, YJ Yeh, CC Wei… - Journal of Hazardous …, 2024 - Elsevier
Per-and polyfluoroalkyl substances (PFAS) is a large compound class (n> 12,000) that is
extensively present in food, drinking water, and aquatic environments. Reduced serum …
extensively present in food, drinking water, and aquatic environments. Reduced serum …