The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

Cancer is a multistep disease driven by the activation of specific oncogenic pathways
concomitantly with the loss of function of tumor suppressor genes that act as sentinels to …

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

In this FlyBook chapter, we present a survey of the current literature on the development of
the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of …

Establishment and maintenance of the blood system relies on self-renewing hematopoietic
stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult …

Gut homeostasis is controlled by both immune and developmental mechanisms, and its
disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the …

Reactive oxygen species (ROS), produced during various electron transfer reactions in vivo,
are generally considered to be deleterious to cells. In the mammalian haematopoietic …

Stem cells self-renew but also give rise to daughter cells that are committed to lineage-
specific differentiation. To achieve this remarkable task, they can undergo an intrinsically …

The Drosophila lymph gland, the larval hematopoietic organ comprised of prohemocytes
and mature hemocytes, has been a valuable model for understanding mechanisms …

Background Gut homeostasis is central to whole organism health, and its disruption is
associated with a broad range of pathologies. Following damage, complex physiological …