Telomere replication: solving multiple end replication problems

E Bonnell, E Pasquier, RJ Wellinger - Frontiers in Cell and …, 2021 - frontiersin.org
Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …

Mechanisms of alternative lengthening of telomeres

RJ O'Sullivan, RA Greenberg - Cold Spring Harbor …, 2025 - cshperspectives.cshlp.org
In recent years, significant advances have been made in understanding the intricate details
of the mechanisms underlying alternative lengthening of telomeres (ALT). Studies of a …

A unified alternative telomere-lengthening pathway in yeast survivor cells

ZW Kockler, JM Comeron, A Malkova - Molecular cell, 2021 - cell.com
Alternative lengthening of telomeres (ALT) is a recombination process that maintains
telomeres in the absence of telomerase and helps cancer cells to survive. Yeast has been …

Multigaps embedded nanoassemblies enhance in situ Raman spectroscopy for intracellular telomerase activity sensing

L Xu, S Zhao, W Ma, X Wu, S Li… - Advanced Functional …, 2016 - Wiley Online Library
The highly sensitive and quantitative biodetection of intracellular telomerase is challenging.
A DNA‐driven nanoparticle self‐assembling pyramid encoding a Raman reporter (Cy5) is …

Live cell microscopy: From image to insight

AP Cuny, FP Schlottmann, JC Ewald, S Pelet… - Biophysics …, 2022 - pubs.aip.org
Live-cell microscopy is a powerful tool that can reveal cellular behavior as well as the
underlying molecular processes. A key advantage of microscopy is that by visualizing …

Microfluidic technologies for yeast replicative lifespan studies

KL Chen, MM Crane, M Kaeberlein - Mechanisms of ageing and …, 2017 - Elsevier
The budding yeast Saccharomyces cerevisiae has been used as a model organism for the
study of aging for over 50 years. In this time, the canonical aging experiment—replicative …

Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability

H Coutelier, Z Xu, MC Morisse… - Genes & …, 2018 - genesdev.cshlp.org
In cells lacking telomerase, telomeres gradually shorten during each cell division to reach a
critically short length, permanently activate the DNA damage checkpoint, and trigger …

The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA

P Pizzul, C Rinaldi, D Bonetti - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Replicative senescence is an essential cellular process playing important physiological
functions, but it is better known for its implications in aging, cancer, and other pathologies …

Target-triggered Au NPs self-assembled for fluorescence-SERS dual-mode monitoring of telomerase in living cells and in vivo

F Shen, S Xie, H Yan, Y Li, S Dong, X Zhang… - Sensors and Actuators B …, 2023 - Elsevier
Telomerase was regarded as a pivotal tumor marker for cancers diagnosis and prognosis
evaluation. Hence, the accurate quantification detection and distribution information of …

The nuclear pore complex prevents sister chromatid recombination during replicative senescence

P Aguilera, J Whalen, C Minguet, D Churikov… - Nature …, 2020 - nature.com
Abstract The Nuclear Pore Complex (NPC) has emerged as an important hub for processing
various types of DNA damage. Here, we uncover that fusing a DNA binding domain to the …