Cancer is the second leading cause of death in the US. Current major treatments for cancer
management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy …

Purines have key roles in neurotransmission and neuromodulation, with their effects being
mediated by the purine and pyrimidine receptor subfamilies, P1, P2X and P2Y. Recently …

Background There is growing awareness that tumour cells build up a “self-advantageous”
microenvironment that reduces effectiveness of anti-tumour immune response. While many …

Purines were long thought to be restricted to the intracellular compartment, where they are
used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical …

Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

Background Glioblastomas are the most common and lethal primary brain tumors. Microglia,
the resident immune cells of the brain, survey their environment and respond to pathogens …

Astrocytes are fundamental for central nervous system (CNS) physiology and are the fulcrum
of neurological diseases. Astroglial cells control development of the nervous system …

The ectonucleotidases CD39 and CD73 degrade immune stimulatory ATP to adenosine that
inhibits T and NK cell responses via the A 2A adenosine receptor (ADORA2A). This …

Previous studies suggested that curcumin is a potential agent against glioblastomas
(GBMs). However, the in vivo efficacy of curcumin in gliomas remains not established. In this …

Glioblastoma is the worst and most common primary brain tumor. Here, we demonstrated
the role of CD73, an enzyme responsible for adenosine (ADO) production, in glioblastoma …