The avermectins and milbemycins contain a common macrocyclic lactone (ML) ring, but are
fermentation products of different organisms. The principal structural difference is that …

Veterinary medicine faces the unique challenge of having to treat many types of domestic
animal species, including mammals, birds, and fishes. Moreover, these species have …

The pharmacokinetic properties of drugs are closely related to their pharmacological
efficacy. The kinetics of ivermectin are characterised, in general terms, by a slow absorption …

Due to the intensification of dairy herds and the recognition of subclinical infections with a
negative impact on production as disease, control of gastrointestinal (GI) nematodes in adult …

The macrocyclic lactones (MLs) are probably the anti-parasitic agents most widely used in
the treatment of food producing animals, poultry, aquaculture and crops. Ivermectin was the …

ATP-binding cassette (ABC) transporters are efflux transporters found in all organisms.
These proteins are responsible for pumping xenobiotic and endogenous metabolites …

The pharmacokinetics and mammary excretion of eprinomectin were determined in cattle
following topical administration at a dose rate of 0· 5 mg kg–1. The kinetics of plasma and …

Pour-on formulations of endectocides are extensively used to treat and control systemic
parasitic diseases in cattle, worldwide. The purpose of the present study was to investigate …

The efficacy of moxidectin administered by different routes, against naturally acquired
infections of gastrointestinal nematode parasites of cattle, was compared using faecal egg …

Internal parasites of horses comprise an intractable problem conferring disease, production
and performance losses. Parasitism can rarely be controlled in grazing horses by …