The basic science of the subchondral bone

H Madry, CN van Dijk, M Mueller-Gerbl - Knee surgery, sports …, 2010 - Springer
In the past decades, considerable efforts have been made to propose experimental and
clinical treatments for articular cartilage defects. Yet, the problem of cartilage defects …

Subject-specific analysis of joint contact mechanics: application to the study of osteoarthritis and surgical planning

CR Henak, AE Anderson… - Journal of …, 2013 - asmedigitalcollection.asme.org
Advances in computational mechanics, constitutive modeling, and techniques for subject-
specific modeling have opened the door to patient-specific simulation of the relationships …

Validation of finite element predictions of cartilage contact pressure in the human hip joint

AE Anderson, BJ Ellis, SA Maas, CL Peters… - 2008 - asmedigitalcollection.asme.org
Methods to predict contact stresses in the hip can provide an improved understanding of
load distribution in the normal and pathologic joint. The objectives of this study were to …

Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering

RL Mauck, SB Nicoll, SL Seyhan, GA Ateshian… - Tissue …, 2003 - liebertpub.com
It has previously been demonstrated that dynamic deformational loading of chondrocyte-
seeded agarose hydrogels over the course of 1 month can increase construct mechanical …

Finite element prediction of cartilage contact stresses in normal human hips

MD Harris, AE Anderson, CR Henak… - Journal of …, 2012 - Wiley Online Library
Our objectives were to determine cartilage contact stress during walking, stair climbing, and
descending stairs in a well‐defined group of normal volunteers and to assess variations in …

Influence of seeding density and dynamic deformational loading on the developing structure/function relationships of chondrocyte-seeded agarose hydrogels

RL Mauck, SL Seyhan, GA Ateshian… - Annals of biomedical …, 2002 - Springer
Chondrocytes cultured in agarose hydrogels develop a functional extracellular matrix.
Application of dynamic strain at physiologic levels to these constructs over time can increase …

Effects of idealized joint geometry on finite element predictions of cartilage contact stresses in the hip

AE Anderson, BJ Ellis, SA Maas, JA Weiss - Journal of biomechanics, 2010 - Elsevier
Computational models may have the ability to quantify the relationship between hip
morphology, cartilage mechanics and osteoarthritis. Most models have assumed the hip …

Tissue stresses and strain in trabeculae of a canine proximal femur can be quantified from computer reconstructions

B Van Rietbergen, R Müller, D Ulrich… - Journal of …, 1999 - Elsevier
A quantitative assessment of bone tissue stresses and strains is essential for the
understanding of failure mechanisms associated with osteoporosis, osteoarthritis, loosening …

Cartilage contact pressure elevations in dysplastic hips: a chronic overload model

ME Russell, KH Shivanna, NM Grosland… - Journal of orthopaedic …, 2006 - Springer
Background Developmental dysplasia of the hip (DDH) is a condition in which bone growth
irregularities subject articular cartilage to higher mechanical stresses, increase susceptibility …

The distribution of cartilage thickness within the joints of the lower limb of elderly individuals

C ADAM, F Eckstein, S MILZ, R PUTZ - The Journal of Anatomy, 1998 - cambridge.org
The objective of this study was to investigate the normal distribution of cartilage thickness in
the major joints of the lower limb in elderly individuals. A 12.5 MHz ultrasound transducer …