Pancreatic β-cell electrical activity and insulin secretion: of mice and men
P Rorsman, FM Ashcroft - Physiological reviews, 2018 - journals.physiology.org
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
Regulation of insulin secretion in human pancreatic islets
P Rorsman, M Braun - Annual review of physiology, 2013 - annualreviews.org
Pancreatic β cells secrete insulin, the body's only hormone capable of lowering plasma
glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β …
glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β …
Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes
Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …
The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance
In β cells, stimulation by metabolic, hormonal, neuronal, and pharmacological factors is
coupled to secretion of insulin through different intracellular signaling pathways. Our …
coupled to secretion of insulin through different intracellular signaling pathways. Our …
[HTML][HTML] Beta-cell ion channels and their role in regulating insulin secretion
B Thompson, LS Satin - Comprehensive physiology, 2021 - ncbi.nlm.nih.gov
Beta cells of the pancreatic islet express many different types of ion channels. These
channels reside in the β-cell plasma membrane as well as subcellular organelles and their …
channels reside in the β-cell plasma membrane as well as subcellular organelles and their …
Synaptotagmin 4 regulates pancreatic β cell maturation by modulating the Ca2+ sensitivity of insulin secretion vesicles
Islet β cells from newborn mammals exhibit high basal insulin secretion and poor glucose-
stimulated insulin secretion (GSIS). Here we show that β cells of newborns secrete more …
stimulated insulin secretion (GSIS). Here we show that β cells of newborns secrete more …
Photoswitchable diacylglycerols enable optical control of protein kinase C
Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream
signaling events including the translocation of C1-domain-containing proteins toward the …
signaling events including the translocation of C1-domain-containing proteins toward the …
Ionic mechanisms in pancreatic β cell signaling
SN Yang, Y Shi, G Yang, Y Li, J Yu… - Cellular and Molecular …, 2014 - Springer
The function and survival of pancreatic β cells critically rely on complex electrical signaling
systems composed of a series of ionic events, namely fluxes of K+, Na+, Ca 2+ and Cl …
systems composed of a series of ionic events, namely fluxes of K+, Na+, Ca 2+ and Cl …
The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes
JW Ramadan, SR Steiner, CM O'Neill, CS Nunemaker - Cell calcium, 2011 - Elsevier
The appropriate regulation of intracellular calcium is a requirement for proper cell function
and survival. This review focuses on the effects of proinflammatory cytokines on calcium …
and survival. This review focuses on the effects of proinflammatory cytokines on calcium …
Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans
When exposed to intermediate glucose concentrations (6–16 mol/l), pancreatic β-cells in
intact islets generate bursts of action potentials (superimposed on depolarised plateaux) …
intact islets generate bursts of action potentials (superimposed on depolarised plateaux) …