Maturity-onset diabetes of the young (MODY): current perspectives on diagnosis and treatment

T Urakami - Diabetes, metabolic syndrome and obesity: targets and …, 2019 - Taylor & Francis
Maturity-onset diabetes of the young (MODY) is characterized by autosomal dominant
inheritance, onset before 25 years of age, absence of β-cell autoimmunity, and sustained …

Biology of human sodium glucose transporters

EM Wright, DDF Loo, BA Hirayama - Physiological reviews, 2011 - journals.physiology.org
There are two classes of glucose transporters involved in glucose homeostasis in the body,
the facilitated transporters or uniporters (GLUTs) and the active transporters or symporters …

The molecular functions of hepatocyte nuclear factors–In and beyond the liver

HH Lau, NHJ Ng, LSW Loo, JB Jasmen, AKK Teo - Journal of hepatology, 2018 - Elsevier
The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and
ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas …

SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects

E Ferrannini, A Solini - Nature Reviews Endocrinology, 2012 - nature.com
This Review covers the rationale, physiological consequences and clinical application of
pharmacological sodium–glucose cotransporter 2 (SGLT2) inhibition. In patients with type 2 …

Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

SS Fajans, GI Bell, KS Polonsky - New England Journal of …, 2001 - Mass Medical Soc
Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of
disorders characterized by nonketotic diabetes mellitus, an autosomal dominant mode of …

Maturity-onset diabetes of the young (MODY): an update

A Anık, G Çatlı, A Abacı, E Böber - Journal of pediatric endocrinology …, 2015 - degruyter.com
Maturity-onset diabetes of the young (MODY) is a group of monogenic disorders
characterized by autosomal dominantly inherited non-insulin dependent form of diabetes …

Glucose transport families SLC5 and SLC50

EM Wright - Molecular aspects of medicine, 2013 - Elsevier
There are three families of glucose transporters in the human genome, SLC2, SLC5 and
SLC50. Here I review the structure and function of the SLC5 and SLC50 genes. The human …

Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target

R Santer, J Calado - Clinical Journal of the American Society of …, 2010 - journals.lww.com
Four members of two glucose transporter families, SGLT1, SGLT2, GLUT1, and GLUT2, are
differentially expressed in the kidney, and three of them have been shown to be necessary …

Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha and 4 alpha in maturity‐onset diabetes of the young and hyperinsulinemic …

K Colclough, C Bellanne‐Chantelot… - Human …, 2013 - Wiley Online Library
Maturity‐onset diabetes of the young (MODY) is a monogenic disorder characterized by
autosomal dominant inheritance of young‐onset (typically< 25 years), noninsulin …

High basolateral glucose increases sodium-glucose cotransporter 2 and reduces sirtuin-1 in renal tubules through glucose transporter-2 detection

H Umino, K Hasegawa, H Minakuchi, H Muraoka… - Scientific reports, 2018 - nature.com
Under diabetic conditions, sodium–glucose cotransporter 2 (SGLT2) for glucose uptake in
proximal tubules (PTs) increases, whereas NAD+-dependent protein deacetylase silent …