Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

Motivation Understanding functions of proteins in specific human tissues is essential for
insights into disease diagnostics and therapeutics, yet prediction of tissue-specific cellular …

We have developed a new generation of genome-wide DNA methylation BeadChip which
allows high-throughput methylation profiling of the human genome. The new high density …

DNA methylation is the most widely studied epigenetic mark and is known to be essential to
normal development and frequently disrupted in disease. The Illumina …

As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …

Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …

DNA methylation has become increasingly recognized in the etiology of psychiatric
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …

Epigenetic control of gene transcription is critical for normal human development and
cellular differentiation. While alterations of epigenetic marks such as DNA methylation have …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …