Investigating the mechanism of inhibition of cyclin-dependent kinase 6 inhibitory potential by selonsertib: Newer insights into drug repurposing
Cyclin-dependent kinases (CDKs) play significant roles in numerous physiological, and are
considered an attractive drug target for cancer, neurodegenerative, and inflammatory …
considered an attractive drug target for cancer, neurodegenerative, and inflammatory …
Quantum Dynamics and Bi Metal Force Field Parameterization Yielding Significant Antileishmanial Targets
Amid emerging drug resistance to metal inhibitors, high toxicity, and onerous drug delivery
procedures, the computational design of alternate formulations encompassing functional …
procedures, the computational design of alternate formulations encompassing functional …
Probing the Interaction of Selonsertib with Human Serum Albumin: In silico and In vitro Approaches
Introduction: Selonsertib, the most recently developed selective inhibitor of apoptosis signal-
regulating kinase 1. We elucidated the binding characteristics, mechanism of interaction …
regulating kinase 1. We elucidated the binding characteristics, mechanism of interaction …
Structural and molecular dynamic studies of Pseudomonas aeruginosa OdaA reveal the regulation role of a C-terminal hinge element
Background Crotonase superfamily members exhibit great catalytic diversity towards various
acyl-CoA substrates. A common CoA moiety binding pattern is usually observed in this …
acyl-CoA substrates. A common CoA moiety binding pattern is usually observed in this …