The environmental and metabolic pressures in the tumor microenvironment (TME) play a
key role in molding tumor development by impacting the stromal and immune cell fractions …

Cancer is one of the leading non-communicable diseases with highest mortality rates
worldwide. About half of all cancer patients receive radiation treatment in the course of their …

Treatment of metastatic colorectal cancer is based upon the assumption that metastases are
homogeneous within a patient. We quantified immune cell types of 603 whole-slide …

Preoperative bevacizumab and chemotherapy may benefit a subset of breast cancer (BC)
patients. To explore potential mechanisms of this benefit, we conducted a phase II study of …

Tumour hypoxia contributes to poor treatment outcome in locally advanced rectal cancer
(LARC) and circulating extracellular vesicles (EVs) as potential biomarkers of tumour …

Colorectal cancer (CRC) biopsies underpin accurate diagnosis, but are also relevant for
patient stratification in molecularly‐guided clinical trials. The consensus molecular subtypes …

Background Precision oncology is gradually advancing into mainstream clinical practice,
demonstrating significant survival benefits. However, eligibility and response rates remain …

Simple Summary Rectal cancer is the 8th most common cancer globally. Most patients with
locally advanced rectal cancer receive neoadjuvant therapy based on 5-fluorouracil and …

Abstract Protein arginine methyltransferase 5 (PRMT5) is a type of methyltransferase
enzyme that can catalyse arginine methylation of histones and non‐histone proteins …

Background Radiosensitivity of rectal cancer is related to the radiotherapy efficacy and
prognosis of patients with rectal cancer, and the genes and molecular mechanisms related …