Global scanning of selective serotonin reuptake inhibitors: occurrence, wastewater treatment and hazards in aquatic systems

RA Mole, BW Brooks - Environmental Pollution, 2019 - Elsevier
As the global population becomes more concentrated in urban areas, resource
consumption, including access to pharmaceuticals, is increasing and chemical use is also …

Proximate causes and ultimate effects of common antidepressants, fluoxetine and venlafaxine, on fish behavior

A Salahinejad, A Attaran, D Meuthen… - Science of The Total …, 2022 - Elsevier
Antidepressant (AD) drugs are widely prescribed for the treatment of psychiatric disorders,
including depression and anxiety disorders. The continuous use of ADs causes significant …

The potential for adverse effects in fish exposed to antidepressants in the aquatic environment

SL Gould, MJ Winter, WHJ Norton… - … Science & Technology, 2021 - ACS Publications
Antidepressants are one of the most commonly prescribed pharmaceutical classes for the
treatment of psychiatric conditions. They act via modulation of brain monoaminergic …

[HTML][HTML] Pharmacology beyond the patient–The environmental risks of human drugs

L Gunnarsson, JR Snape, B Verbruggen… - Environment …, 2019 - Elsevier
Background The presence of pharmaceuticals in the environment is a growing global
concern and although environmental risk assessment is required for approval of new drugs …

The occurrence of typical psychotropic drugs in the aquatic environments and their potential toxicity to aquatic organisms-A review

X Zhu, T Luo, D Wang, Y Zhao, Y Jin, G Yang - Science of The Total …, 2023 - Elsevier
Psychotropic drugs (PDs) and their bioactive metabolites often persist in aquatic
environments due to their typical physical properties, which made them resistant to removal …

[HTML][HTML] Effects of fluoxetine on fish: What do we know and where should we focus our efforts in the future?

D Correia, I Domingues, M Faria, M Oliveira - Science of the Total …, 2023 - Elsevier
Fluoxetine is one of the most studied and detected selective serotonin reuptake inhibitors in
the aquatic environment, found at concentrations ranging from ng/L to μg/L. Its presence in …

Neurotoxic effects of synthetic phenolic antioxidants on dopaminergic, serotoninergic, and GABAergic signaling in larval zebrafish (Danio rerio)

Z Shi, X Liang, Y Zhao, W Liu, CJ Martyniuk - Science of the Total …, 2022 - Elsevier
Synthetic phenolic antioxidants (SPAs) are an environmental concern because they are
widely detected in aquatic ecosystems and can pose potential threats to organisms. Studies …

Anti-depressant fluoxetine hampers olfaction of goldfish by interfering with the initiation, transmission, and processing of olfactory signals

L Huang, W Zhang, Y Han, Y Tang… - Environmental …, 2022 - ACS Publications
The ubiquitous presence of fluoxetine (FLX) in aquatic environments poses great threat to
fish species. However, little is known about its deleterious impacts on fish olfaction. In this …

Depressed, hypertense and sore: Long-term effects of fluoxetine, propranolol and diclofenac exposure in a top predator fish

IA Duarte, P Reis-Santos, SC Novais, LD Rato… - Science of the total …, 2020 - Elsevier
Pharmaceutical compounds are continuously released into the aquatic environment,
resulting in their ubiquitous presence in many estuarine and coastal systems. As …

[HTML][HTML] Impact of environmentally relevant concentrations of fluoxetine on zebrafish larvae: from gene to behavior

D Correia, M Bellot, E Prats, C Gómez-Canela, H Moro… - Chemosphere, 2023 - Elsevier
Fluoxetine is widely prescribed for the treatment of depressive states, acting at the level of
the central nervous system, consequently affecting non-target organisms. This study aimed …