COVID-19 and the chemical senses: supporting players take center stage

KW Cooper, DH Brann, MC Farruggia, S Bhutani… - Neuron, 2020 - cell.com
The main neurological manifestation of COVID-19 is loss of smell or taste. The high
incidence of smell loss without significant rhinorrhea or nasal congestion suggests that …

Mechanisms of SARS-CoV-2-associated anosmia

T Tsukahara, DH Brann, SR Datta - Physiological Reviews, 2023 - journals.physiology.org
Anosmia, the loss of the sense of smell, is one of the main neurological manifestations of
COVID-19. Although the SARS-CoV-2 virus targets the nasal olfactory epithelium, current …

COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice

J Zheng, LYR Wong, K Li, AK Verma, ME Ortiz… - Nature, 2021 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic is associated with substantial
morbidity and mortality. Although much has been learned in the first few months of the …

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

DH Brann, T Tsukahara, C Weinreb, M Lipovsek… - Science …, 2020 - science.org
Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A
key question is whether SARS-CoV-2 (CoV-2)–the causal agent in COVID-19–affects …

[PDF][PDF] Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients

D Brann, T Tsukahara, C Weinreb, DW Logan… - BioRxiv, 2020 - biorxiv.org
Recent reports suggest an association between COVID-19 and altered olfactory function.
Here we analyze bulk and single cell RNA-Seq datasets to identify cell types in the olfactory …

The influences of age on olfaction: a review

RL Doty, V Kamath - Frontiers in psychology, 2014 - frontiersin.org
Decreased olfactory function is very common in the older population, being present in over
half of those between the ages of 65 and 80 years and in over three quarters of those over …

Ca2+-activated Cl currents are dispensable for olfaction

GM Billig, B Pál, P Fidzinski, TJ Jentsch - Nature neuroscience, 2011 - nature.com
Canonical olfactory signal transduction involves the activation of cyclic AMP–activated
cation channels that depolarize the cilia of receptor neurons and raise intracellular calcium …

[图书][B] Neuroglia: function and pathology

A Verkhratsky, A Butt - 2023 - books.google.com
Diverse specialised neuroglial cells guarantee the development, preservation, and health of
the central nervous system, the peripheral nervous system, the enteric nervous system, and …

Mechanistic understanding of the olfactory neuroepithelium involvement leading to short-term anosmia in COVID-19 using the adverse outcome pathway framework

MA Shahbaz, F De Bernardi, A Alatalo, M Sachana… - Cells, 2022 - mdpi.com
Loss of the sense of smell (anosmia) has been included as a COVID-19 symptom by the
World Health Organization. The majority of patients recover the sense of smell within a few …

[HTML][HTML] Quantitative assessment of olfactory dysfunction accurately detects asymptomatic COVID-19 carriers

AS Bhattacharjee, SV Joshi, S Naik, S Sangle… - …, 2020 - thelancet.com
Background COVID-19 threatens the global community because a large fraction of infected
people are asymptomatic, yet can effectively transmit SARS-CoV-2. Finding and isolating …