With the development and regulatory approval of immune checkpoint inhibitors and adoptive
cell therapies, cancer immunotherapy has undergone a profound transformation over the …

By exerting pro-and anti-tumorigenic actions, tumor-infiltrating immune cells can profoundly
influence tumor progression, as well as the success of anti-cancer therapies. Therefore, the …

Gene expression profiling is nowadays routinely performed on clinically relevant samples
(eg, from tumor specimens). Such measurements are often obtained from bulk samples …

We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from
bulk RNA-sequencing data. quanTIseq was extensively validated in blood and tumor …

Cancer immunotherapy has experienced remarkable advances in recent years. Striking
clinical responses have been achieved for several types of solid cancers (eg melanoma …

Neoantigens are newly formed peptides created from somatic mutations that are capable of
inducing tumor-specific T cell recognition. Recently, researchers and clinicians have …

The remarkable success of cancer therapies with immune checkpoint blockers is
revolutionizing oncology and has sparked intensive basic and translational research into the …

Background The use of next-generation sequencing technologies has enabled the rapid
identification of non-synonymous somatic mutations in cancer cells. Neoantigens are …

T cells play a crucial role in controlling and driving the immune response with their ability to
discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we …

Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising
approach for cancer therapy with an expectation of no significant side effects. In the human …